Protein Name:
WD repeat-containing protein 1
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UniprotKB/SwissProt ID: O75083 (O75083)
Gene Name:
WDR1
Organism: Homo sapiens (Human)
Function: Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, podosome. Cell junction
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O75083
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
170 |
YRLATGSDDN C AAFFEGPPFK |
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| 2 |
194 |
TIGDHSRFVN C VRFSPDGNRF |
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| 3 |
225 |
IYDGKTGEKV C ALGGSKAHDG |
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| 4 |
325 |
VIKGHSKSIQ C LTVHKNGGKS |
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| 5 |
382 |
TVDESGQLIS C SMDDTVRYTS |
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| 6 |
438 |
QIVLLKDQRK C FSIDNPGYEP |
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