Protein Name:
Four and a half LIM domains protein 2
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UniprotKB/SwissProt ID: O70433 (O70433)
Gene Name:
Fhl2
Organism: Mus musculus (Mouse)
Function: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:22851699)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O70433
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
132 |
WHETCFTCQR C QQPIGTKSFI |
CCCCCCCCCC C HHHCCCEEEE |
1.49% |
21278135
|
| 2 |
221 |
TCFCDLYAKK C AGCTNPISGL |
CCCCCCCCCC C HHHCCCEEEE |
3.76% |
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| 3 |
224 |
CDLYAKKCAG C TNPISGLGGT |
CCCCCCCCCC C HHHCCCEEEE |
1.44% |
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| 4 |
254 |
WHNDCFNCKK C SLSLVGRGFL |
CCCCCCCCCC C HHHCCCEEEE |
2.79% |
21278135
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| 5 |
71 |
WHEGCFHCSR C GSSLVDKPFA |
CCCCCCCCCC C HHHCCCEEEE |
3.4% |
21278135
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