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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein diaphanous homolog 2

UniprotKB/SwissProt ID: O60879 (O60879)

Gene Name: DIAPH2

Organism: Homo sapiens (Human)

Function: Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Early endosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR014767 DAD_dom
IPR044933 DIA_GBD_sf
IPR015425 FH2_Formin
IPR042201 FH2_Formin_sf
IPR010472 FH3_dom
IPR051412 Formin_Homology_Diaphanous_sf
IPR014768 GBD/FH3_dom
IPR010473 GTPase-bd

The S-nitrosylation sites of O60879

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 159 SGGLKNSKHE C TLSSQEYVHE