Protein Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
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UniprotKB/SwissProt ID: O60566 (O60566)
Gene Name:
BUB1B
Organism: Homo sapiens (Human)
Function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O60566
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
656 |
VKTSEDQQTA C GTIYSQTLSI |
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| 2 |
700 |
ASVASTSSIK C LQIPEKLELT |
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| 3 |
723 |
TSENPTQSPW C SQYRRQLLKS |
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| 4 |
900 |
LRNRIHDPYD C NKNNQALKIV |
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