UniprotKB/SwissProt ID: O60565 (O60565)
Gene Name:
GREM1
Organism: Homo sapiens (Human)
Function: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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