Protein Name:
Long-chain-fatty-acid--CoA ligase 4
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UniprotKB/SwissProt ID: O60488 (O60488)
Gene Name:
ACSL4
Organism: Homo sapiens (Human)
Function: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially activates arachidonate and eicosapentaenoate as substrates (PubMed:21242590). Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (PubMed:21242590)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Peroxisome membrane. Microsome membrane. Endoplasmic reticulum membrane. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O60488
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
157 |
LKPKNTIAIF C ETRAEWMIAA |
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| 2 |
221 |
KLKTALLDIS C VKHIIYVDNK |
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| 3 |
363 |
SKIKKGSKGD C TVLKPTLMAA |
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| 4 |
420 |
QIKKGYDAPL C NLLLFKKVKA |
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| 5 |
472 |
IGQGYGLTES C GAGTVTEVTD |
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| 6 |
494 |
TTGRVGAPLI C CEIKLKDWQE |
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| 7 |
552 |
SVDENGQRWF C TGDIGEFHPD |
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| 8 |
602 |
LKNCPLIDNI C AFAKSDQSYV |
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