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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: TBC1 domain family member 4

UniprotKB/SwissProt ID: O60343 (O60343)

Gene Name: TBC1D4

Organism: Homo sapiens (Human)

Function: May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR021785 DUF3350
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR000195 Rab-GAP-TBC_dom
IPR035969 Rab-GAP_TBC_sf
IPR050302 Rab_GAP_TBC_domain

The S-nitrosylation sites of O60343

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 207 YNSQKFEVLY C GKVTVTHKKA   
2 295 SQPALTSSRV C FPERILEDSG   
3 45 RFRLWYVGGS C LDHRTTLPML   
4 74 RRSQKPEAGG C GAPAAREVIL   
5 885 VKLDYEEVGA C QKEVLITWDK