Protein Name:
E3 ubiquitin-protein ligase MGRN1
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UniprotKB/SwissProt ID: O60291 (O60291)
Gene Name:
MGRN1
Organism: Homo sapiens (Human)
Function: E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome. Cytoplasm, cytosol. Nucleus. Cytoplasm, cytosol. Nucleus. Cytoplasm, cytosol. Cell membrane. Cytoplasm, cytosol. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O60291
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
546 |
IYLPALGPDS C SVGIDE---- |
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