Protein Name:
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16
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UniprotKB/SwissProt ID: O60231 (O60231)
Gene Name:
DHX16
Organism: Homo sapiens (Human)
Function: Required for pre-mRNA splicing as a component of the spliceosome (PubMed:20423332, PubMed:20841358, PubMed:25296192, PubMed:29360106). Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA (PubMed:35263596). Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses (PubMed:35263596)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus, nucleoplasm. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O60231
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
450 |
GYTNKGMKIA C TQPRRVAAMS |
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| 2 |
486 |
EVGYSIRFED C TSERTVLRYM |
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| 3 |
714 |
TGMESLTVTP C SKASANQRAG |
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| 4 |
932 |
LERVEVGLSS C QGDYIRVRKA |
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