Protein Name:
Protein NipSnap homolog 2
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UniprotKB/SwissProt ID: O55126 (O55126)
Gene Name:
Nipsnap2
Organism: Mus musculus (Mouse)
Function: Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (By similarity). May act as a positive regulator of L-type calcium channels (PubMed:22627147)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O55126
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
103 |
PKIHEGKQYP C TLVGTWNTWY |
CCHHHHHHCC C CHHHHHHHHC |
3.8% |
21278135
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| 2 |
80 |
KLQFHNVKPE C LDAYNKICQE |
CCHHHHHHCC C CHHHHHHHHC |
5.9% |
21278135
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| 3 |
88 |
PECLDAYNKI C QEVLPKIHEG |
CCHHHHHHCC C CHHHHHHHHC |
2.77% |
21278135
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