Protein Name:
Deoxyribonuclease gamma
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UniprotKB/SwissProt ID: O55070 (O55070)
Gene Name:
Dnase1l3
Organism: Mus musculus (Mouse)
Function: Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA (PubMed:12095301, PubMed:15796714, PubMed:19154352). Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self-reactive B cells (PubMed:12050166, PubMed:15167901, PubMed:17218958, PubMed:24312463). Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmunity (PubMed:15796714, PubMed:27293190). Together with DNASE1, plays a key role in degrading neutrophil extracellular traps (NETs) (PubMed:29191910). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:29191910). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (PubMed:29191910)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Endoplasmic reticulum. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O55070
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
73 |
MEIKDSSNNI C PMLMEKLNGN |
CCCCCCCHHH H HHHHHHHHHH |
1.44% |
21278135
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