Protein Name:
Membrane-associated progesterone receptor component 1
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UniprotKB/SwissProt ID: O55022 (O55022)
Gene Name:
Pgrmc1
Organism: Mus musculus (Mouse)
Function: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Microsome membrane. Endoplasmic reticulum membrane. Mitochondrion outer membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O55022
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
RDASRGLATF C LDKEALKDEY |
CCHHCHHCCC C CHHHHCCCCH |
4.11% |
22178444
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