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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Pectinesterase/pectinesterase inhibitor 3

UniprotKB/SwissProt ID: O49006 (O49006)

Gene Name: PME3

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Acts in the modification of cell walls via demethylesterification of cell wall pectin (PubMed:21171891, PubMed:26183897). Required for zinc Zn(2+) homeostasis and to monitor Zn(2+) influence on cell wall-controlled growth processes such as root cell elongation (PubMed:23826687). Monitors seed germination and favors root hairs production (PubMed:28375469). Prevents cruciferin seed storage proteins activity, but promotes the expression of genes involved in cell wall organization and remodeling as well as genes involved in lipid and protein metabolism, during post-germinative growth of seedlings (PubMed:28375469). Confers sensitivity to Zn(2+) when overexpressed (PubMed:23826687). Acts as a susceptibility factor required for the initial colonization of the host tissue by virulent pathogens including Botrytis cinerea and Pectobacterium carotovorum, probably by facilitating cell wall pectine degradation by pathogen pectic enzymes after its demethylesterification (PubMed:21171891)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space, apoplast. Secreted, cell wall

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR035513 Invertase/methylesterase_inhib
IPR012334 Pectin_lyas_fold
IPR011050 Pectin_lyase_fold/virulence
IPR033131 Pectinesterase_Asp_AS
IPR000070 Pectinesterase_cat
IPR006501 Pectinesterase_inhib_dom
IPR018040 Pectinesterase_Tyr_AS

The S-nitrosylation sites of O49006

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 206 LKGQIHVEHM C SNALAMIKNM