Protein Name:
Peroxisomal ATPase PEX1
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UniprotKB/SwissProt ID: O43933 (O43933)
Gene Name:
PEX1
Organism: Homo sapiens (Human)
Function: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling (PubMed:11439091, PubMed:16314507, PubMed:16854980, PubMed:21362118, PubMed:29884772). Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel (PubMed:29884772). Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5 (PubMed:29884772)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Peroxisome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43933
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1005 |
RPGRLDKCVY C PPPDQVSRLE |
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| 2 |
1185 |
PVLRTASQEG C QELTQEQRDQ |
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| 3 |
27 |
VTVAFTNARD C FLHLPRRLVA |
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| 4 |
629 |
KLDAHVERVD C KALRGKRLEN |
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| 5 |
733 |
VSAQGVHIFQ C VQHIQPPNQE |
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| 6 |
750 |
PNQEQRCEIL C NVIKNKLDCD |
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| 7 |
759 |
LCNVIKNKLD C DINKFTDLDL |
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