Protein Name:
Nardilysin
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UniprotKB/SwissProt ID: O43847 (O43847)
Gene Name:
NRDC
Organism: Homo sapiens (Human)
Function: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Cell projection, dendrite
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43847
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1027 |
QVTALIKLKE C EDTHLGEEVD |
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| 2 |
269 |
HGGSDNASTD C ERTVFQFDVQ |
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| 3 |
62 |
GRNKAKSTCS C PDLQPNGQDL |
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| 4 |
674 |
ATDFTLKAFD C PETEYPVKIV |
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| 5 |
690 |
PVKIVNTPQG C LWYKKDNKFK |
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| 6 |
966 |
QTLGYHVYPT C RNTSGILGFS |
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