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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutathione S-transferase LANCL1

UniprotKB/SwissProt ID: O43813 (O43813)

Gene Name: LANCL1

Organism: Homo sapiens (Human)

Function: Functions as a glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (By similarity). May play a role in EPS8 signaling. Binds glutathione (PubMed:19528316)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR012341 6hp_glycosidase-like_sf
IPR007822 LANC-like
IPR020464 LanC-like_prot_euk

The S-nitrosylation sites of O43813

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 183 KIPQSHIQQI C ETILTSGENL   
2 264 LKFPSGNYPP C IGDNRDLLVH   
3 300 YKVFREEKYL C DAYQCADVIW   
4 355 LYRACKFAEW C LEYGEHGCRT   
5 98 AHGYVKQSLN C LTKRSITFLC