Protein Name:
Asparagine--tRNA ligase, cytoplasmic
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UniprotKB/SwissProt ID: O43776 (O43776)
Gene Name:
NARS1
Organism: Homo sapiens (Human)
Function: Catalyzes the attachment of asparagine to tRNA(Asn) in a two-step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn) (PubMed:32738225, PubMed:32788587, PubMed:9421509). In addition to its essential role in protein synthesis, acts as a signaling molecule that induced migration of CCR3-expressing cells (PubMed:12235211, PubMed:30171954). Has an essential role in the development of the cerebral cortex, being required for proper proliferation of radial glial cells (PubMed:32788587)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43776
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
114 |
KNDPSLPEPK C VKIGALEGYR |
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| 2 |
342 |
LAEYTHVEAE C PFLTFDDLLN |
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| 3 |
359 |
DLLNRLEDLV C DVVDRILKSP |
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| 4 |
438 |
TDTINEPILL C RFPVEIKSFY |
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| 5 |
511 |
WYTDQRKYGT C PHGGYGLGLE |
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| 6 |
537 |
ILNRYHIRDV C LYPRFVQRCT |
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