Protein Name:
Small glutamine-rich tetratricopeptide repeat-containing protein alpha
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UniprotKB/SwissProt ID: O43765 (O43765)
Gene Name:
SGTA
Organism: Homo sapiens (Human)
Function: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457) (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43765
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
129 |
ELNPANAVYF C NRAAAYSKLG |
CCHHHHHHHH H HHHHHHHHHC |
1.52% |
19483679
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| 2 |
148 |
LGNYAGAVQD C ERAICIDPAY |
CCHHHHHHHH H HHHHHHHHHC |
1.82% |
19483679
2212679
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| 3 |
153 |
GAVQDCERAI C IDPAYSKAYG |
CCHHHHHHHH H HHHHHHHHHC |
2.55% |
19483679
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