Protein Name:
Alpha-actinin-4
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UniprotKB/SwissProt ID: O43707 (O43707)
Gene Name:
ACTN4
Organism: Homo sapiens (Human)
Function: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation (PubMed:22689882)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cell junction. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, perinuclear region
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43707
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
173 |
TSAKEGLLLW C QRKTAPYKNV |
CCCCCCCCCC C CCCCCCCCCC |
2.57% |
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| 2 |
351 |
VHKPPKVQEK C QLEINFNTLQ |
CCCCCCCCCC C CCCCCCCCCC |
5.7% |
22178444
37478858
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| 3 |
499 |
HNVNTRCQKI C DQWDALGSLT |
CCCCCCCCCC C CCCCCCCCCC |
4.02% |
22178444
20140087
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| 4 |
60 |
KQQRKTFTAW C NSHLRKAGTQ |
CCCCCCCCCC C CCCCCCCCCC |
3.29% |
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| 5 |
793 |
GALGPEEFKA C LISLGYDVEN |
CCCCCCCCCC C CCCCCCCCCC |
3.41% |
22178444
20140087
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| 6 |
879 |
RELPPDQAEY C IARMAPYQGP |
CCCCCCCCCC C CCCCCCCCCC |
1.15% |
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