Protein Name:
Mitotic checkpoint protein BUB3
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UniprotKB/SwissProt ID: O43684 (O43684)
Gene Name:
BUB3
Organism: Homo sapiens (Human)
Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome, centromere, kinetochore
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43684
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
101 |
LVGTHDAPIR C VEYCPEVNVM |
CCCCCCCCCC C CCCCCCCCEE |
2.56% |
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| 2 |
129 |
TVKLWDPRTP C NAGTFSQPEK |
CCCCCCCCCC C CCCCCCCCEE |
5.57% |
2212679
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| 3 |
184 |
RESSLKYQTR C IRAFPNKQGY |
CCCCCCCCCC C CCCCCCCCEE |
2.54% |
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| 4 |
270 |
IWDPFNKKRL C QFHRYPTSIA |
CCCCCCCCCC C CCCCCCCCEE |
4.76% |
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| 5 |
327 |
TDAETKPKSP C T--------- |
CCCCCCCCCC C CCCCCCCCEE |
10.21% |
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| 6 |
62 |
KYQHTGAVLD C AFYDPTHAWS |
CCCCCCCCCC C CCCCCCCCEE |
2.17% |
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