Protein Name:
Protein regulator of cytokinesis 1
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UniprotKB/SwissProt ID: O43663 (O43663)
Gene Name:
PRC1
Organism: Homo sapiens (Human)
Function: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Midbody. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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| InterPro ID |
Domain Name |
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IPR007145
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MAP65_Ase1_PRC1 |
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The S-nitrosylation sites of O43663
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
14 |
SEVLAEESIV C LQKALNHLRE |
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| 2 |
202 |
PDTSFERDVV C EDEDAFCLSL |
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| 3 |
236 |
EMQKSQNEAV C EGLRTQIREL |
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| 4 |
322 |
QEQRQAFAPF C AEDYTESLLQ |
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