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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cytoplasmic protein NCK2

UniprotKB/SwissProt ID: O43639 (O43639)

Gene Name: NCK2

Organism: Homo sapiens (Human)

Function: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Endoplasmic reticulum

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR017304 NCK
IPR035883 Nck2_SH2
IPR035559 Nck2_SH3_1
IPR035560 Nck2_SH3_2
IPR035561 Nck2_SH3_3
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR051184 Tyrosine-phos_adapter

The S-nitrosylation sites of O43639

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 144 KGSRVTVMEK C SDGWWRGSYN   
2 343 FKVQLVDNVY C IGQRRFHTMD