Protein Name:
Aflatoxin B1 aldehyde reductase member 2
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UniprotKB/SwissProt ID: O43488 (O43488)
Gene Name:
AKR7A2
Organism: Homo sapiens (Human)
Function: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Golgi apparatus. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43488
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
132 |
QLETSLKRLQ C PQVDLFYLHA |
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| 2 |
156 |
GTPVEETLHA C QRLHQEGKFV |
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