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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Peptidyl-prolyl cis-trans isomerase H

UniprotKB/SwissProt ID: O43447 (O43447)

Gene Name: PPIH

Organism: Homo sapiens (Human)

Function: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus speckle. Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom

The S-nitrosylation sites of O43447

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 131 GCQFFITCSK C DWLDGKHVVF  CCCCCCCCCC C EEEEEEEECC  2.33% 19483679
2 174 KPKLPVVISQ C GEM-------  CCCCCCCCCC C EEEEEEEECC  3.88%
3 47 PKTAENFRQF C TGEFRKDGVP  CCCCCCCCCC C EEEEEEEECC  3.46%