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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eukaryotic translation initiation factor 4 gamma 3

UniprotKB/SwissProt ID: O43432 (O43432)

Gene Name: EIF4G3

Organism: Homo sapiens (Human)

Function: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain

The S-nitrosylation sites of O43432

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1245 HINDFKEAMQ C VEELNAQGLL   
2 1411 KLDFIESDSP C SSEALSKKEL   
3 301 PIFTTAIDDR C ELSSPREDTI   
4 319 DTIPIPSLTS C TETSDPLPTN   
5 461 VLEEDESIRT C LSEDAKEIQN   
6 913 KMLTEAIMHD C VVKLLKNHDE   
7 928 LKNHDEESLE C LCRLLTTIGK   
8 930 NHDEESLECL C RLLTTIGKDL