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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: WD repeat-containing protein 62

UniprotKB/SwissProt ID: O43379 (O43379)

Gene Name: WDR62

Organism: Homo sapiens (Human)

Function: Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20729831, PubMed:20890278). Plays a role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011047 Quinoprotein_ADH-like_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR056161 WD40_MABP1-WDR62_1st
IPR056162 WD40_MABP1-WDR62_2nd
IPR036322 WD40_repeat_dom_sf
IPR001680 WD40_rpt
IPR052779 WDR62
IPR056364 WDR62-MABP1_CC

The S-nitrosylation sites of O43379

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1001 DSGESEADLE C SFAAIHSPAP   
2 959 VTVTGTDSQY C RKEVEAGPGD