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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ras GTPase-activating protein 4

UniprotKB/SwissProt ID: O43374 (O43374)

Gene Name: RASA4

Organism: Homo sapiens (Human)

Function: Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Cell membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR039360 Ras_GTPase
IPR037777 RASA4_PH
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif

The S-nitrosylation sites of O43374

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 176 TRETSIVKKS C YPRWNETFEF   
2 30 KDITGSSDPY C IVKVDNEPII   
3 396 PSKVEVKDVG C SGLHRPQTEA   
4 655 AGRPQTAYLQ C KCVNELNQWL   
5 694 PGVFRGDKWS C CHQKEKTGQG   
6 695 GVFRGDKWSC C HQKEKTGQGC   
7 705 CHQKEKTGQG C DKTRSRVTLQ   
8 88 LSRDDVIGKV C LTRDTIASHP