Protein Name:
Centromere/kinetochore protein zw10 homolog
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UniprotKB/SwissProt ID: O43264 (O43264)
Gene Name:
ZW10
Organism: Homo sapiens (Human)
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:15029241)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Endoplasmic reticulum membrane. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Lipid droplet
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43264
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
124 |
EFSTAIEEYN C ALTEKKYVTG |
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| 2 |
404 |
NINSHFANKK C QDVIVAARNL |
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| 3 |
568 |
QFRLRLAPIL C DGTATFVDLV |
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| 4 |
588 |
VPGFRRLGTE C FLAQMRAQKG |
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| 5 |
686 |
TEDGDRLYSL C KTVMDEGPQV |
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