Protein Name:
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1
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UniprotKB/SwissProt ID: O43252 (O43252)
Gene Name:
PAPSS1
Organism: Homo sapiens (Human)
Function: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:14747722, PubMed:9576487, PubMed:9648242, PubMed:9668121). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43252
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
207 |
APELVLKTDS C DVNDCVQQVV |
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| 2 |
212 |
LKTDSCDVND C VQQVVELLQE |
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| 3 |
323 |
THEDKERLDG C TAFALMYEGR |
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| 4 |
360 |
ERCARQWGTT C KNHPYIKMVM |
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