Protein Name:
D-3-phosphoglycerate dehydrogenase
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UniprotKB/SwissProt ID: O43175 (O43175)
Gene Name:
PHGDH
Organism: Homo sapiens (Human)
Function: Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43175
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
18 |
KVLISDSLDP C CRKILQDGGL |
CCCCCHHHHH H HCCCCHHHHH |
3.32% |
|
| 2 |
19 |
VLISDSLDPC C RKILQDGGLQ |
CCCCCHHHHH H HCCCCHHHHH |
6.37% |
|
| 3 |
234 |
QCKKGVRVVN C ARGGIVDEGA |
CCCCCHHHHH H HCCCCHHHHH |
1.52% |
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| 4 |
254 |
ALLRALQSGQ C AGAALDVFTE |
CCCCCHHHHH H HCCCCHHHHH |
4.26% |
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| 5 |
281 |
ALVDHENVIS C PHLGASTKEA |
CCCCCHHHHH H HCCCCHHHHH |
1.37% |
22178444
18335467
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| 6 |
295 |
GASTKEAQSR C GEEIAVQFVD |
CCCCCHHHHH H HCCCCHHHHH |
11.02% |
37478858
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| 7 |
369 |
QGTSLKNAGN C LSPAVIVGLL |
CCCCCHHHHH H HCCCCHHHHH |
3.78% |
18335467
19483679
22178444
19101475
37478858
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| 8 |
48 |
KEELIAELQD C EGLIVRSATK |
CCCCCHHHHH H HCCCCHHHHH |
2.63% |
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