Protein Name:
E3 ubiquitin-protein ligase Praja-2
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UniprotKB/SwissProt ID: O43164 (O43164)
Gene Name:
PJA2
Organism: Homo sapiens (Human)
Function: Has E2-dependent E3 ubiquitin-protein ligase activity (PubMed:12036302, PubMed:21423175). Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). Plays a role in ciliogenesis by ubiquitinating OFD1 (PubMed:33934390)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Synapse. Postsynaptic density. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43164
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
105 |
FEKSETEIPT C GSALNQTTES |
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| 2 |
224 |
GLSPPVPSFN C EVRDEFEELD |
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