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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: mRNA cap guanine-N(7) methyltransferase

UniprotKB/SwissProt ID: O43148 (O43148)

Gene Name: RNMT

Organism: Homo sapiens (Human)

Function: Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871, PubMed:9705270, PubMed:9790902). Binds RNA containing 5'-terminal GpppC (PubMed:11114884)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004971 mRNA_G-N7_MeTrfase_dom
IPR016899 mRNA_G-N7_MeTrfase_euk
IPR039753 RG7MT1
IPR029063 SAM-dependent_MTases_sf

The S-nitrosylation sites of O43148

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 206 KRDITVLDLG C GKGGDLLKWK   
2 225 WKKGRINKLV C TDIADVSVKQ   
3 73 EDDLVKESSS C GKDTPSKKRK   
4 95 DPEIVPEEKD C GDAEGNSKKR