Protein Name:
ATP-dependent RNA helicase DHX15
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UniprotKB/SwissProt ID: O43143 (O43143)
Gene Name:
DHX15
Organism: Homo sapiens (Human)
Function: RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:19103666, PubMed:19432882, PubMed:24782566, PubMed:24990078, PubMed:32179686, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (PubMed:19103666). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (PubMed:19103666). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:24782566, PubMed:24990078, PubMed:34161762). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (PubMed:24782566, PubMed:24990078, PubMed:34161762). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:34161762). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O43143
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
174 |
SGKTTQIPQW C VEYMRSLPGP |
CCCCCCCCCC C CCCCCCCCCC |
1.08% |
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| 2 |
190 |
SLPGPKRGVA C TQPRRVAAMS |
CCCCCCCCCC C CCCCCCCCCC |
3.18% |
19483679
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| 3 |
226 |
EVGYSIRFED C SSAKTILKYM |
CCCCCCCCCC C CCCCCCCCCC |
2.45% |
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| 4 |
307 |
AGKFQIYFDN C PLLTIPGRTH |
CCCCCCCCCC C CCCCCCCCCC |
2.43% |
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| 5 |
644 |
FKQNHESVQW C YDNFINYRSL |
CCCCCCCCCC C CCCCCCCCCC |
1.38% |
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| 6 |
750 |
VLTTKNYIRT C TDIKPEWLVK |
CCCCCCCCCC C CCCCCCCCCC |
2.01% |
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| 7 |
774 |
QYYDMSNFPQ C EAKRQLDRII |
CCCCCCCCCC C CCCCCCCCCC |
5.82% |
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