UniprotKB/SwissProt ID: O35728 (O35728)
Gene Name:
Cyp4a14
Organism: Mus musculus (Mouse)
Function: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids (PubMed:17112342). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:17112342). Catalyzes the hydroxylation of saturated carbon hydrogen bonds of fatty acids (PubMed:17112342). May act as a major omega- and ommega-1 hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:17112342). Catalyzes with low efficiency the epoxidation of 11,12-double bond of arachidonic acid (PubMed:17112342)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Microsome membrane
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