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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Betaine--homocysteine S-methyltransferase 1

UniprotKB/SwissProt ID: O35490 (O35490)

Gene Name: Bhmt

Organism: Mus musculus (Mouse)

Function: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol. Nucleus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR017226 Betaine-hCys_S-MeTrfase_BHMT
IPR051524 BHMT
IPR003726 HCY_dom
IPR036589 HCY_dom_sf

The S-nitrosylation sites of O35490

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 104 ISGQKVNEAA C DIARQVADEG  CCCCCCHHHH C CHHHHHCCCC  5.11%
2 131 GVSQTPSYLS C KSEVEVKKIF  CCCCCCHHHH C CHHHHHCCCC  5.33% 22178444
3 217 KAGASIVGVN C HFDPSVSLQT  CCCCCCHHHH C CHHHHHCCCC  2.92% 22178444
4 256 SQPLAYHTPD C GKQGFIDLPE  CCCCCCHHHH C CHHHHHCCCC  8.47% 22178444
5 299 YNLGVRYIGG C CGFEPYHIRA  CCCCCCHHHH C CHHHHHCCCC  1.4% 22178444
6 300 NLGVRYIGGC C GFEPYHIRAI  CCCCCCHHHH C CHHHHHCCCC  8.71% 22178444