Protein Name:
Peptidyl-prolyl cis-trans isomerase FKBP8
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UniprotKB/SwissProt ID: O35465 (O35465)
Gene Name:
Fkbp8
Organism: Mus musculus (Mouse)
Function: Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O35465
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
264 |
EEELLQLKVK C LNNLAASQLK |
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| 2 |
285 |
LDHYRAALRS C SQVLEHQPDN |
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