Protein Name:
Serine protease hepsin
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UniprotKB/SwissProt ID: O35453 (O35453)
Gene Name:
Hpn
Organism: Mus musculus (Mouse)
Function: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2 (By similarity). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Apical cell membrane. Cell membrane. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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