UniprotKB/SwissProt ID: O35310 (O35310)
Gene Name:
Hs3st1
Organism: Mus musculus (Mouse)
Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:15060080, PubMed:9346953). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:15060080, PubMed:9346953). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:15060080, PubMed:9346953)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus lumen
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