UniprotKB/SwissProt ID: O35298 (O35298)
Gene Name:
Aoah
Organism: Mus musculus (Mouse)
Function: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS) (PubMed:12810692, PubMed:15155618, PubMed:17322564, PubMed:19860560). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (PubMed:17322564, PubMed:19860560, PubMed:28622363). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (PubMed:18779055)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Cytoplasmic vesicle
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