UniprotKB/SwissProt ID: O35295 (O35295)
Gene Name:
Purb
Organism: Mus musculus (Mouse)
Function: Transcriptional regulator which can act as an activator or a repressor (PubMed:11751932, PubMed:12874279, PubMed:27064749, PubMed:31918924, PubMed:33743134, PubMed:9334258). Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT-containing element in the 5' flanking region of the gene (PubMed:11751932, PubMed:12874279, PubMed:27064749, PubMed:9334258). Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC-specific isoforms (PubMed:33743134). Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (PubMed:31918924). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (By similarity). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element (By similarity). Modulates constitutive liver galectin-3 gene transcription by binding to its promoter (By similarity). May play a role in the dendritic transport of a subset of mRNAs (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus
|
|
|
