Protein Name:
26S proteasome non-ATPase regulatory subunit 4
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UniprotKB/SwissProt ID: O35226 (O35226)
Gene Name:
Psmd4
Organism: Mus musculus (Mouse)
Function: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O35226
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
37 |
QAQQDAVNIV C HSKTRSNPEN |
CCCCEEEEEE C CHHHHHCCCC |
2.38% |
20925432
21278135
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| 2 |
87 |
TVQPKGKITF C TGIRVAHLAL |
CCCCEEEEEE C CHHHHHCCCC |
2.26% |
20925432
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