Protein Name:
Vacuolar protein sorting-associated protein 26C
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UniprotKB/SwissProt ID: O35075 (O35075)
Gene Name:
Vps26c
Organism: Mus musculus (Mouse)
Function: Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (By similarity). Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (By similarity). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (By similarity). In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O35075
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
137 |
SLLAKDLTKT C EFIVHSAPQK |
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