Protein Name:
Sphingomyelin phosphodiesterase 3
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UniprotKB/SwissProt ID: O35049 (O35049)
Gene Name:
Smpd3
Organism: Rattus norvegicus (Rat)
Function: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location (By similarity). Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. May be involved in IL-1-beta-induced JNK activation in hepatocytes. May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus membrane. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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