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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Adenosylhomocysteinase 1
UniprotKB/SwissProt ID: O23255 (O23255)

Gene Name: SAHH1

Organism: Arabidopsis thaliana (Mouse-ear cress)

Function: Essential protein during embryogenesis (PubMed:15266054). Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine (PubMed:15659630). Required for DNA methylation-dependent gene silencing (PubMed:15659630)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR042172 Adenosylhomocyst_ase-like_sf
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
The S-nitrosylation sites of O23255
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 120 KGETLQEYWW C TERALDWGPG  CCEEEEECCC C CEEEEEECHH  1.43%
2 244 TKSKFDNLYG C RHSLPDGLMR  CCEEEEECCC C CEEEEEECHH  1.92% 22115780
15734904
3 268 VMIAGKVAVI C GYGDVGKGCA  CCEEEEECCC C CEEEEEECHH  2.49% 22115780
15734904
4 346 MRKMKNNAIV C NIGHFDNEID  CCEEEEECCC C CEEEEEECHH  2.22%
5 86 ALGAEVRWCS C NIFSTQDHAA  CCEEEEECCC C CEEEEEECHH  4.03%