UniprotKB/SwissProt ID: O18404 (O18404)
Gene Name:
scu
Organism: Drosophila melanogaster (Fruit fly)
Function: Mitochondrial dehydrogenase involved in pathways of fatty acid, and steroid metabolism (PubMed:12917011). Versatile enzyme presenting two types of activity; L-3-hydroxyacyl-CoA dehydrogenase ((3S)-3-hydroxyacyl-CoA dehydrogenase) activity and hydroxysteroid dehydrogenase (HSD) activity with a wide substrate spectrum. As a (3S)-3-hydroxyacyl-CoA dehydrogenase, it functions in the third step of the fatty acid beta-oxidation pathway, a major metabolic process in which fatty acids are oxidized to provide a significant source of energy, while also generating acyl-CoA metabolites used by many metabolic routes (Probable) (PubMed:12917011). As a HSD, it functions in the degradation pathways of glucocorticoids and sex steroids and epimerization of bile acids; catalyzes the beta-oxidation at position 17 of androgens and estrogens, has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone, and carries out oxidative conversions of 7-beta-hydroxylated bile acids like ursodeoxycholate or isoursodeoxycholate (also known as 3-beta,7-beta-dihydroxy-5-beta-cholan-24-oate or 7-beta-hydroxyisolithocholate, respectively). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (PubMed:12917011). Essential for structural and functional integrity of mitochondria (PubMed:27131785, PubMed:34199774, PubMed:35663400). Required for cell survival during embryonic development (PubMed:9585418). May play a role in germline formation (PubMed:12917011, PubMed:9585418) In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:27131785, PubMed:34199774, PubMed:35663400). Essential for the structural and functional integrity of mitochondria (PubMed:27131785, PubMed:34199774, PubMed:35663400). Function is essential for pupal development (PubMed:27131785, PubMed:34199774)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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