Protein Name:
CASP8 and FADD-like apoptosis regulator
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UniprotKB/SwissProt ID: O15519 (O15519)
Gene Name:
CFLAR
Organism: Homo sapiens (Human)
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O15519
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
254 |
YKMKSKPLGI C LIIDCIGNET |
CCHHHHHHHH H HHCCCHHHHH |
1.8% |
22178444
16246840
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| 2 |
259 |
KPLGICLIID C IGNETELLRD |
CCHHHHHHHH H HHCCCHHHHH |
2.78% |
22178444
16246840
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