Protein Name:
Nuclear valosin-containing protein-like
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UniprotKB/SwissProt ID: O15381 (O15381)
Gene Name:
NVL
Organism: Homo sapiens (Human)
Function: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). Involved in both early and late stages of the pre-rRNA processing pathways (PubMed:26166824). Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus (PubMed:15469983, PubMed:16782053, PubMed:26456651, PubMed:29107693). Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity (PubMed:26456651, PubMed:28416111, PubMed:29107693)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O15381
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
192 |
KKDSFFLDLS C EKSNPKKPIT |
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| 2 |
431 |
RRAGRFDREI C LGIPDEASRE |
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| 3 |
448 |
ASRERILQTL C RKLRLPQAFD |
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| 4 |
484 |
LMALCREAAM C AVNRVLMKLQ |
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| 5 |
687 |
VIFFDEVDAL C PRRSDRETGA |
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| 6 |
803 |
LSALVREASI C ALRQEMARQK |
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