Protein Name:
Eukaryotic translation initiation factor 3 subunit D
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UniprotKB/SwissProt ID: O15371 (O15371)
Gene Name:
EIF3D
Organism: Homo sapiens (Human)
Function: mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs (PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:18599441, PubMed:25849773). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). In the eIF-3 complex, EIF3D specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs (PubMed:27462815) (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O15371
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
19 |
IQDNPSGWGP C AVPEQFRDMP |
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| 2 |
195 |
LEVSEPQDIE C CGALEYYDKA |
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| 3 |
196 |
EVSEPQDIEC C GALEYYDKAF |
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| 4 |
258 |
TDAILATLMS C TRSVYSWDIV |
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| 5 |
327 |
TYINHNFSQQ C LRMGKERYNF |
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| 6 |
375 |
LGDDIDLIVR C EHDGVMTGAN |
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| 7 |
404 |
KTLNEWDSRH C NGVDWRQKLD |
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| 8 |
437 |
NNSYKLARWT C CALLAGSEYL |
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| 9 |
493 |
SVENAWGILR C VIDICMKLEE |
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