Protein Name:
NF-kappa-B-repressing factor
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UniprotKB/SwissProt ID: O15226 (O15226)
Gene Name:
NKRF
Organism: Homo sapiens (Human)
Function: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleolus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O15226
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
115 |
FSIQDGNSQY C DSSGFILTKD |
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| 2 |
246 |
LTDGYACEVR C QNIYLTTGYA |
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| 3 |
37 |
SKGQKRHLST C DGQNPPKKQA |
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| 4 |
453 |
VVYENSSNPV C TLNDTAQFNR |
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