Protein Name:
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
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UniprotKB/SwissProt ID: O15084 (O15084)
Gene Name:
ANKRD28
Organism: Homo sapiens (Human)
Function: Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. Involved in the PP6-mediated dephosphorylation of MOB1 and induced focal adhesion assembly during cell migration (PubMed:35512830)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus, nucleoplasm. Cytoplasm, cytosol. Cell projection, lamellipodium
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of O15084
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
122 |
HIAAANKAVK C AEALVPLLSN |
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| 2 |
201 |
LLVSHGAEVT C KDKKSYTPLH |
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| 3 |
334 |
TIIQSGAVID C EDKNGNTPLH |
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| 4 |
487 |
YAATSDTDGK C LEYLLRNDAN |
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